In this course we will give an overview of multiple testing issues and adaptive designs in trials. Participants will learn about a variety of new adaptive clinical trial designs, including multi-arm multi-stage (MAMS), umbrella studies and adaptive randomisation. As well as learning about how to design adaptive trials we will cover the implications of the design on the analysis and practical aspects of running the trial.
Throughout the course, real examples will be used to demonstrate the methodology. There will be a strong emphasis on learning how to use available software (in both R and Stata) to implement the methodology in practice.

Course tutors:

Dr Michael Grayling, Janssen
Dr David Robertson, MRC Biostatistics Unit, University of Cambridge
Professor James Wason, Newcastle University